By Ramana S. Moorthy MD
Starts off with an in-depth assessment of immunemedicated eye illness, summarizing uncomplicated immunologic thoughts, ocular immune responses and designated themes in ocular immunology. Discusses the scientific method of uveitis and studies noninfectious (autoimmune) and infectious kinds of uveitis, with an increased part on viral uveitis and new fabric on infectious and noninfectious scleritis. greater detection of infectious brokers through immunologic and genetic tools and new biologic therapeutics are specific. additionally covers endophthalmitis, masquerade syndromes, issues of uveitis and ocular features of AIDS. features a variety of new colour pictures. significant revision 2011-2012
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Additional resources for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)
Previously primed DH CD4 T lymphocytes leave the lymph node, home into local tissues where antigen persists, and become activated by further restimulation with the specific priming antigen and MHC class II - expressing CLINICAL EXAMPLE 2·2 Identification of rubella virus reactivity in Fuchs heterochromic iridocyclitis Fuchs heterochromic iridocyclitis (FHI) is a unilateral chronic anterior uveitis that frequently features elevated intraocular pressure, early cata ract, and iris atrophy leading to heterochromia.
Illustration by Barb Cousins. ) IL-4, IL-S, and IL- IO but not Thl cytokines. In recent yea rs, 2 additional T-cell subsets have b een recognized. Th l 7 cells are so- named because th ey produce IL- 17, as well as IL-2 1 and -22. Thl7 cells have been implicated in a number of au toi m mune conditions, including som e forms of uveitis. T regulatory (Treg) cells form another subset of helper T cells; they are identified not by their cytokine profile but by the simulta neous surface expression ofCD4, CD2S, and Foxp3.
In many cases, both CDS and CD4 regulatory T lymphocytes appear to operate by the release of immunomodulatory cytokines such as transforming growth factor ~, which can inhibit or alter the effector function of other T lymphocytes. Regulatory T lymphocytes are potentially important as they may provide a means for induction of tolerance to specific antigens. 42 • Intraocular Inflammation and Uveiti s Effector Phase During the effector phase, the adaptive immune response (eg, the elimination of offen ding foreign antige n) is physically carried out.