By David Y. Hwang
50 reviews each Neurologist should still Know offers key experiences that form the present medical perform of neurology. All neurologic subspecialties are coated, with a unique emphasis on neurocritical care and vascular neurology. for every examine, a concise precis is gifted with an emphasis at the effects and boundaries of the examine, and its implications for perform. An illustrative scientific case concludes each one evaluation, by means of short details on different appropriate reports. this is often the 1st booklet of its style to give a set of the main influential scientific trials in neurology which are targeted sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for overall healthiness care pros and someone who desires to examine extra in regards to the info at the back of scientific practice.
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Extra resources for 50 studies every neurologist should know
Hanney M, Prasher V, Williams N, et al. Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double- blind, placebo- controlled trial. Lancet. 2012;379(9815):528–536. For FTLD (for this study, behavioral variant FTD or semantic dementia): Boxer AL, Knopman DS, Kaufer DI, et al. Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double- blind, placebo-controlled trial. Lancet Neurol. 2013;12(2):149–156. 16.
2009;8(7):613–618; (2) Emre M, Tsolaki M, Bonuccelli U, et al. Memantine for patients with Parkinson’s disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010;9(10):969–977. The AAN’s evidence classification criteria include study completion rates; studies with completion rates below 80% are downgraded. 12. The prior trial of memantine monotherapy in patients with moderate-to-severe AD also had both a high exclusion rate and a high dropout rate.
1] of more than 4 at screening”5 (to exclude patients with presumed vascular dementia). 1. , AD). Scores ≥4 are more consistent with multi-infarct (vascular) dementia. The Ischemic Score does not differentiate between patients with multi-infarct dementia alone and patients with both disorders (multi-infarct dementia and a primary neurodegenerative disease). Pathological verification of Ischemic Score in differentiation of dementias. Ann Neurol. 1980;7(5):486–488. For the original Ischemic Score, with 13 rather than 8 items: Hachinski VC, Illff LD, Zilhka E, et al.